Specific cellular biomarkers for canine’s breast cancer: literature review

  • Frederico Ozanan Barros Monteiro UFRA
  • Priscilla Del Aguila Silva UNESP/Jaboticabal
  • Gabriela Noronha Toledo UNESP
  • Barbara Nascimento Borges UFRA
  • Marcus Antonio Rossi Feliciano UNESP/Jaboticabal

Resumo

Although there are many studies about the cellular biomarkers’ use in canine’s mammary cancer, the results are not to compare. This paper offers orientations about the most useful immunohistochemical markers, which can help to treat canine’s mammal tumors. The main biomarkers of the canines’ mammal epithelia and of the myoepithelial cells were reviewed and based on that, some orientations about immunoexpression of cadherin (E cadherin and P cadherin), proliferation marker (Ki-67), Human Epidermal Growth Factor (HER2 and HER3), estrogen and progesterone receptors were made. The incorporation of these information in future studies, either they be prospective or retrospective, will offer mechanisms that allow the direct comparison of the studies, and therefore will help to determine if the biomarkers have prognostic significance. The use of these biomarkers can help to point out the most adequate treatment to malignant canine’s mammal cancers.

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Referências

ADELFINGER, M.; BESSLER, S.; FRENTZEN, A.; CECIL, A.; LANGBEIN-LAUGWITZ, J.; GENTSCHEV, I.; SZALAY, A.A. Preclinical Testing Oncolytic Vaccinia Virus Strain GLV-5b451 Expressing an Anti-VEGF Single-Chain Antibody for Canine Cancer Therapy. Viruses, v. 7, n. 7, p. 4075-4092, 2015.

BERTAGNOLLI, A.C.; FERREIRA, E.; DIAS, E.J.; CASSALI, G.D. Canine mammary mixed tumours: immunohistochemical expressions of EGFR and HER-2. Australian Veterinary Journal, v.89, p.312-317, 2011.

BORGATTI, A.; DUCKETT, M.; SPANGLER, C.; MODIANO, J.F. Binding of VEGF-A to canine cancer cells with preferential expression of VEGFR1. Veterinary World, v. 7, n. 1, p. 1-6, 2014.

CARVALHO, M.I.; PIRES, I.; PRADA, J.; RAPOSO, T.P.; GREGÓRIO, H.; LOBO, L.; QUEIROGA, F.L. High COX-2 expression is associated with increased angiogenesis, proliferation and tumoural inflammatory infiltrate in canine malignant mammary tumours: a multivariate survival study. Veterinary and Comparative Oncology, 2016 Jan 21. doi: 10.1111/vco.12206. [Epub ahead of print].

CASSALI, G.D.; LAVALLE, G.E.; DE NARDI, A.B.; FERREIRA, E.; BERTAGNOLLI, A.C.; ESTRELA-LIMA, A.; ALESSI, A.C.; DALECK, C.R.; SALGADO, B.S.; FERNANDES, C.G.; SOBRAL, R.A.; AMORIM, R.L. GAMBA, C.O.; DAMASCENO, K.A.; AULER, P.A.; MAGALHÃES, G.M.; SILVA, J.O.; RAPOSO, J.B.; FERREIRA, A.M.R.; OLIVEIRA, L.O.; MALM, C.; ZUCCARI, D.A. P.C.; TANAKA, N.M.; RIBEIRO, L.R.; CAMPOS, L.C.; SOUZA, C.M.; LEITE, J.S.; SOARES, L.M.C.; CAVALCANTI, M.F.; FONTELES, Z.G.C.; SCHUCH, I.D.; PANIAGO, J.; OLIVEIRA, T.S.; TERRA, E.M.; CASTANHEIRA, T.L.L.; FELIX, A.O.C.; CARVALHO, G.D.; GUIM, T.N.; GUIM, T.N.; GARRIDO, E.; FERNANDES, S.C.; MAIA, F.C.L.; DAGLI, M.L.Z.; ROCHA, N.S.; FUKUMASU, H.; GRANDI, F.; MACHADO, J.P.; SILVA, S.M.M.S.; BEZERRIL, J.E.; FREHSE, M.S.; ALMEIDA, E.C.; PAES, C.; CECILIA B. Consensus for the diagnosis, prognosis and treatment of canine mammary tumors. Brazilian Journal of Veterinary Pathology, v.4, n.2, p.153-180, 2011.

COSTA, C.; SOARES, R.; REIS-FILHO, J.S.; LEITÃO, D.; AMENDOEIRA, I.; SCHMITT, F.C. Cyclo-oxygenase 2 expression is associated with angiogenesis and lymph node metastasis in human breast câncer. Journal of Clinical Pathology, v. 55, p. 429–434, 2002.

FELICIANO, M.A.; VICENTE, W.R.; SILVA, M.A. Conventional and Doppler ultrasound for the differentiation of benign and malignant canine mammary tumours. Journal of Small Animal Practice, v. 53, n. 6, p. 332-337, 2012.

GERALDES, M.; GÄRTNER, F.; SCHMITT, F. Immunohistochemical study of hormonal receptors and cell proliferation in normal canine mammary glands and spontaneous mammary tumours. Veterinary Research, v. 146, p. 403–406, 2000.

GUIL-LUNA, S.; STENVANG, J.; BRÜNNER, N.; DE ANDRÉS, F.J.; ROLLÓN, E.; DOMINGO, V.; SÁNCHEZ-CÉSPEDES, R.; MILLÁN, Y.; MARTÍN, DE L.A.S.; MULAS, J. Progesterone receptor isoform A may regulate the effects of neoadjuvant aglepristone in canine mammary carcinoma. BMC Veterinary Research, v. 17, n. 10, p. 296, 2014.

HORTA, R.S.; COSTA, M.P.; LAVALLEII, G.E.; ARAÚJO, R.B.; CASSALI, G.D. Prognostic and predictive factors of canine tumours define with immunohistochemistry’s assistance. Ciência Rural, v.42, n.6, 2012.

KATO, Y.; ASANO, K.; MOGI, T.; KUTARA, K.; TESHIMA, K. EDAMURA, K.; TSUMAGARI, S.; HASEGAWA, A.; TANAKA, S. Clinical significance of circulating vascular endothelial growth factor in dogs with mammary gland tumors. Journal of Veterinary Medical Science, v. 69, n. 1, p, 77-80, 2007.

KIM, J.H.; IM, K.S.; KIM, N.H.; YHEE, J.Y.; NHO, W.G.; SUR, J.H. Expression of HER-2 and nuclear localization of HER-3 protein in canine mammary tumors: histopathological and immunohistochemical study. Veterinary Journal, v. 189, n. 3, p. 318-322, 2011.

KLOPFLEISCH, R.; VON, E.H.; SARLI, G.; PINHO, S.S.; GÄRTNER, F.; GRUBER, A.D. Molecular carcinogenesis of canine mammary tumors: news from an old disease. Veterinary Pathology, v. 48, n. 1, n. 98-116, 2011.

KOUTRAS, A.K.; FOUNTZILAS, G.; KALOGERAS, K.T.; STARAKIS, I.; ICONOMOU, G.;, KALOFONOS, H.P. The upgraded role of HER3 and HER4 receptors in breast cancer. Critical Reviews in Oncology/Hematology, v. 74, p. 73–78, 2010.

LANA, S.E.; RUTTEMAN, G.R.; WITHROW, S.J. Tumors of the mammary gland. In: WITHROW, S.J.; MACEWEN, E.G. Withrow and MacEwen's small animal clinical oncology. 4.ed. Philadelphia: Saunders, 2007. Cap.26, p.619-636.

LAVALLE, G.E.; BERTAGNOLLI, A.C.; TAVARES, W.L.F.; CASSALI, G.D. Cox-2 expression in canine mammary carcinomas: correlation with angiogenesis (or microvessel density) and overall survival. Veterinary Pathology, v.46, p.1-6, 2009.

MATSUMOTO, A.; JINNO, H.; ANDO, T.; FUJII, T.; NAKAMURA, T.; SAITO, J.; TAKAHASHI, M.; HAYASHIDA, T.; KITAGAWA, Y. Biological markers of invasive breast cancer. JPN Journal of Clinical Oncology. 2015 Oct 20. pii: hyv153.

MILLANTA, F.; SILVESTRI, G.; VASELLI, C.; CITI, S.; PISANI, G.; LORENZI, D.; POLI, A. The role of vascular endothelial growth factor and its receptor Flk-1/KDR in promoting tumour angiogenesis in feline and canine mammary carcinomas: a preliminary study of autocrine and paracrine loops. Research in Veterinary Science, v. 81, n. 3, p. 350-357, 2006.

MILLANTA, F.; CANESCHI, V.; RESSEL, L.; CITI, S.; POLI, A. Expression of Vascular Endothelial Growth Factor in Canine Inflammatory and Non-inflammatory Mammary Carcinoma. Journal of Comparative Pathology, v.142, n. 1, p. 36-42, 2010.

MONTEMURRO, F.; DI, C.S.; ARPINO, G. Human epidermal growth factor receptor 2 (HER2)-positive and hormone receptor-positive breast cancer: new insights into molecular interactions and clinical implications. Annual Oncology, v. 24, n. 11, p. 2715-2724, 2013.

MOSCHETTA, M.G.; MASCHIO, L.B.; JARDIM-PERASSI, B.V.; GELALETI, G.B.; LOPES, J.R.; LEONEL, C.; GONÇALVES, N.D.O.N.; FERREIRA, L.C.; MARTINS, G.R.; BORIN, T.F.; ZUCCARI, D.A. Prognostic value of vascular endothelial growth factor and hypoxia-inducible factor 1α in canine malignant mammary tumors. Oncology Reports, v. 33, n. 5, p. 2345-2353, 2015.

PAREDES, J.; CORREIA, A.L.; RIBEIRO, A.S.; ALBERGARIA, A.; MILANEZI, F.; SCHMITT, F.C. P-cadherin expression in breast cancer: a review. Breast Cancer Research, v. ??n. 9, p. 214, 2007.

PEÑA, L.L.; NIETO. A.I.; PEREZ-ALENZA, D.; CUESTA, P.; CASTAÑO, M. Immunohistochemical detection of Ki-67 and PCNA in canine mammary tumors: relationship to clinical and pathologic variables. Veterinary Diagnostic Investigation, v. ??, n. 10, p. 237–246, 1998.

PEÑA, L.; GAMA, A.; GOLDSCHMIDT, M.H.; ABADIE, J.; BENAZZI, C.; CASTAGNARO, M.; DÍEZ, L.; GÄRTNER,F.; HELLMÉN, E.; KIUPEL, M.; MILLÁN, Y.; MILLER, M.A.; NGUYEN, F.; POLI, A.; SARLI, G.; ZAPPULLI, V.; DE LAS MULAS, J.M. Canine mammary tumors: a review and consensus of standard guidelines on epithelial and myoepithelial phenotype markers, HER2, and hormone receptor assessment using immunohistochemistry. Veterinary Pathology, v. 51, n. 1, p. 127-45, 2014.

PEROU, C.M.; SORLIE, T.; EISEN, M.B.; RIJN, M.V.; JEFFREY, S.S.; REES, C.A.; POLLACK, J.R.; ROSS, D.T.; JOHNSEN, H.; AKSLEN, L.A.; FLUGE, O.; PERGAMENSCHIKOV, A.; WILLIAMS, C.; ZHU, S.X.; LONNING, P.E.; BORRESEN-DALE, A.; BROWN, P.O.; BOTSTEIN, D. Molecular portraits of human breast tumours. Nature, v.406, p.747-752, 2000.

PURDIE, C.A.; QUINLAN, P.; JORDAN, L.B.; ASHFIELD, A.; OGSTON, S.; DEWAR, J.A.; THOMPSON, A.M. Progesterone receptor expression is an independent prognostic variable in early breast cancer: a population-based study. British Journal of Cancer, vol, 110 n. 3, p. 565-72, 2014.

QUEIROGA, F.L.; PEREZ-ALENZA, M.D.; SILVAN, G.; PEÑA, L.; LOPES, C.; ILLERA, J.C. Cox-2 levels in canine mammary tumors, including inflammatory mammary carcinoma: clinicopathological features and prognostic significance. Anticancer Research, v. 25, p. 4269–4275, 2005.

QUEIROGA, F.L.; ALVES, A.; PIRES, I; LOPES, C. Expression of Cox-1 and Cox-2 in canine mammary tumours. Journal of Comparative Pathology, v. 136, p. 177–185, 2007.

QUEIROGA, F.L.; PIRES, I.; LOBO, L.; LOPES, C.S. The role of Cox-2 expression in the prognosis of dogs with malignant mammary tumours. Research Veterinary Science, v. 88, n. 3, p. 441-445, 2010.

QUEIROGA, F.L.; PIRES, I.; PARENTE, M.; GREGÓRIO, H.; LOPES, C.S. COX-2 over-expression correlates with VEGF and tumour angiogenesis in canine mammary câncer. Veterinary Journal, v. 189, n. 1, p. 77-82, 2011. doi: 10.1016/j.tvjl.2010.06.022.

QIU, C.W.; LIN, D.G.; WANG, J.Q.; LI, C.Y.; DENG, G.Z. Expression and significance of PTEN and VEGF in canine mammary gland tumours. Veterinary Research Communications, v. 32, n. 6, p. 463-472, 2008a.

QIU, C.; LIN, D.D.; WANG, H.H.; QIAO, C.H.; WANG, J.; ZHANG, T. Quantification of VEGF-C expression in canine mammary tumours. Australian Veterinary Journal, v. 86, n. 7, p. 279-282, 2008.

RAPOSO, T.P.; PIRES, I.; CARVALHO, M.I.; PRADA, J.; ARGYLE, D.J.; QUEIROGA, F.L. Tumour-associated macrophages are associated with vascular endothelial growth factor expression in canine mammary tumours. Veterinary and Comparative Oncology, v.13, n; 4, p. 464-474, 2015.

RAPOSO, T.P; PIRES, I.; PRADA, J.; QUEIROGA, F.L.; ARGYLE, D.J. Exploring new biomarkers in the tumour microenvironment of canine inflammatory mammary tumours. Veterinary and Comparative Oncology, doi: 10.1111/vco.12209, 2016. [Epub ahead of print].

RANZI, A.D.; DA SILVA, J.N.; GRAZIOTTIN, T.M.; ANNELS, N.; BICA, C.G. Immunohistochemistry Biomarkers in Nonmuscle Invasive Bladder Cancer. Applied Immunohistochemistry and Molecular Morphology. 2015 Nov 16. [Epub ahead of print]

RESTUCCI, B.; PAPPARELLA, S.; MAIOLINO, P.; DE VICO, G. Expression of vascular endothelial growth factor in canine mammary tumors. Veterinary Pathology, v. 39, n. 4, p. 488-493, 2002.

SANTOS, A.A.; OLIVEIRA, J.T.; LOPES, C.C.; AMORIM, I.F.; VICENTE, C.M.; GÄRTNER, F.R.; MATOS, A.J. Immunohistochemical expression of vascular endothelial growth factor in canine mammary tumours. Journal of Comparative Pathology, v. 143, n. 4, p. 268-275, 2010.

SANTOS, A.A.; LOPES, C.C.; RIBEIRO, J.R.; MARTINS, L.R.; SANTOS, J.C.; AMORIM, I.F.; GÄRTNER, F.; MATOS, A.J. Identification of prognostic factors in canine mammary malignant tumours: a multivariable survival study. BMC Veterinary Research, v. 9, n. 1, 2013.

SORENMO, K. Canine mammary gland tumors. Veterinary Clinics of North America: Small Animal Practice, v.33, p.573-596, 2003.

TAVARES, W.L.F.; LAVALLE, G.E.; FIGUEIREDO, M.S.; SOUZA, A.G.; BERTAGNOLLI, A.C.; VIANA, F.A.B.; PAES, P.R.O.; CARNEIRO, R.A.; CAVALCANTI, G.A.O.; MELO, M.M.; CASSALI, G.D. Evaluation of adverse effects in tamoxifen exposed healthy female dogs. Acta Veterinaria Scandinavica, v.52, n.67, p.6, 2010.

THURÓCZY, J.; REISVAAG, G.J.; PERGE, E.; TIBOLD, A.; SZILÁGYI, J.; BALOGH, L. Immunohistochemical detection of progesterone and cellular proliferation in canine mammary tumours. Journal of Comparative Pathology, v. 137, n. 2-3, p. 122-92, 2007.

VIALE, G.; ROTMENSZ, N.; MAISONNEUVE, P.; BOTTIGLIERI, L.; MONTAGNA, E.; LUINI, A.; VERONESI, P.; INTRA, M.; TORRISI, R.; CARDILLO, A.; CAMPAGNOLI, E.; GOLDHIRSCH, A.; COLLEONI, M. Invasive ductal carcinoma of the breast with the "triple-negative" phenotype: prognostic implications of EGFR immunoreactivity. Breast Cancer Research and Treatment, v.116, n.2, p.317-328, 2009.

ZUCCARI, D.A.P.C.; SANTANA, A.E.; CURY, P.M.; CORDEIRO, J.A. Immunocytochemical study of Ki-67 as a prognostic marker in canine mammary neoplasia. Veterinary Clinical Pathology, v. 33, p. 23–28, 2004.

Publicado
2016-11-25
Seção
Artigos de Revisão